Home icon showing normal colonic epithelial mucosa

PARKOS and NUSRAT LABORATORIES
Epithelial Pathobiology and Mucosal Inflammation Research Unit

Department of Pathology and Laboratory Medicine
Emory University School of Medicine, Atlanta, Georgia, USA

Our group studies the biology of mucosal epithelia during health and disease. We are particularly interested in understanding mechanisms that regulate intestinal epithelial homeostasis and barrier function under normal and inflammatory conditions.

 

Model schematic of normal epithelial biology in the colon (proliferation, differentiaion, apoptosis) and mucosal inflammation

Using complementary in vivo and in vitro experimental systems, our current projects are focused on understanding the basic mechanisms regulating:

  1. Epithelial intercellular junctions and barrier function
  2. Intestinal epithelial homeostasis
  3. Mucosal wound repair
  4. Immune cell recruitment and interactions with epithelial cells in health and disease