Research articles

Kolegraff K, Nava P, Laur O, Parkos CA, Nusrat A. Characterization of full-length and proteolytic cleavage fragments of desmoglein-2 in native human colon and colonic epithelial cell lines. Cell Adh Migr. 2011 Jul 1;5(4). [Epub ahead of print] PubMed PMID: 21715983.

Swanson PA 2nd, Kumar A, Samarin S, Vijay-Kumar M, Kundu K, Murthy N, Hansen J, Nusrat A, Neish AS. Enteric commensal bacteria potentiate epithelial restitution via reactive oxygen species-mediated inactivation of focal adhesion kinase phosphatases. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8803-8. Epub 2011 May 9. PubMed PMID: 21555563.

Capaldo CT, Koch S, Kwon M, Laur O, Parkos CA, Nusrat A. Tight junction zonula occludens-3 regulates cyclin D1-dependent cell proliferation. Mol Biol Cell. 2011 May;22(10):1677-85. Epub 2011 Mar 16. PubMed PMID: 21411630; PubMed Central PMCID: PMC3093320.

Nava P, Capaldo CT, Koch S, Kolegraff K, Rankin CR, Farkas AE, Feasel ME, Li L, Addis C, Parkos CA, Nusrat A. JAM-A regulates epithelial proliferation through Akt/β-catenin signalling. EMBO Rep. 2011 Apr 1;12(4):314-20. Epub 2011 Mar 4. PubMed PMID: 21372850; PubMed Central PMCID: PMC3077244.

Kolegraff K, Nava P, Helms MN, Parkos CA, Nusrat A. Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β-catenin signaling. Mol Biol Cell. 2011 Apr;22(8):1121-34. Epub 2011 Feb 16. PubMed PMID: 21325624; PubMed Central PMCID: PMC3078068.

Koch S, Nava P, Addis C, Kim W, Denning TL, Li L, Parkos CA, Nusrat A. The Wnt Antagonist Dkk1 Regulates Intestinal Epithelial Homeostasis and Wound Repair. Gastroenterology. 2011 Mar 25. [Epub ahead of print] PubMed PMID: 21440550.

Lee WY, Weber DA, Laur O, Stowell SR, McCall I, Andargachew R, Cummings RD, Parkos CA. The role of cis dimerization of signal regulatory protein alpha (SIRPalpha) in binding to CD47. J Biol Chem. 2010 Dec 3;285(49):37953-63. Epub 2010 Sep 7. PubMed PMID: 20826801; PubMed Central PMCID: PMC2992229.

Wentworth CC, Jones RM, Kwon YM, Nusrat A, Neish AS. Commensal-epithelial signaling mediated via formyl peptide receptors. Am J Pathol. 2010 Dec;177(6):2782-90. Epub 2010 Oct 29. PubMed PMID: 21037077; PubMed Central PMCID: PMC2993286.

Brazil JC, Lee WY, Kolegraff KN, Nusrat A, Parkos CA, Louis NA. Neutrophil migration across intestinal epithelium: evidence for a role of CD44 in regulating detachment of migrating cells from the luminal surface. J Immunol. 2010 Dec 1;185(11):7026-36. Epub 2010 Oct 25. PubMed PMID: 20974992.

Mirpuri J, Brazil JC, Berardinelli AJ, Nasr TR, Cooper K, Schnoor M, Lin PW, Parkos CA, Louis NA. Commensal Escherichia coli reduces epithelial apoptosis through IFN-alphaA-mediated induction of guanylate binding protein-1 in human and murine models of developing intestine. J Immunol. 2010 Jun 15;184(12):7186-95. Epub 2010 May 14. PubMed PMID: 20483731.

Nava P, Koch S, Laukoetter MG, Lee WY, Kolegraff K, Capaldo CT, Beeman N, Addis C, Gerner-Smidt K, Neumaier I, Skerra A, Li L, Parkos CA, Nusrat A. Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways. Immunity. 2010 Mar 26;32(3):392-402. Epub 2010 Mar 18. PubMed PMID: 20303298; PubMed Central PMCID: PMC2859189.

Chin AC, Fournier B, Peatman EJ, Reaves TA, Lee WY, Parkos CA. CD47 and TLR-2 cross-talk regulates neutrophil transmigration. J Immunol. 2009 Nov 1;183(9):5957-63. Epub 2009 Oct 7. PubMed PMID: 19812191; PubMed Central PMCID: PMC2871159.

McCall IC, Betanzos A, Weber DA, Nava P, Miller GW, Parkos CA. Effects of phenol on barrier function of a human intestinal epithelial cell line correlate with altered tight junction protein localization. Toxicol Appl Pharmacol. 2009 Nov 15;241(1):61-70. Epub 2009 Aug 11. PubMed PMID: 19679145; PubMed Central PMCID: PMC2877281.

Koch S, Capaldo CT, Samarin S, Nava P, Neumaier I, Skerra A, Sacks DB, Parkos CA, Nusrat A. Dkk-1 inhibits intestinal epithelial cell migration by attenuating directional polarization of leading edge cells. Mol Biol Cell. 2009 Nov;20(22):4816-25. Epub 2009 Sep 23. PubMed PMID: 19776352; PubMed Central PMCID: PMC2777110.

Babbin BA, Sasaki M, Gerner-Schmidt KW, Nusrat A, Klapproth JM. The bacterial virulence factor lymphostatin compromises intestinal epithelial barrier function by modulating rho GTPases. Am J Pathol. 2009 Apr;174(4):1347-57. Epub 2009 Mar 12. PubMed PMID: 19286565; PubMed Central PMCID: PMC2671366.

Severson EA, Lee WY, Capaldo CT, Nusrat A, Parkos CA. Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration. Mol Biol Cell. 2009 Apr;20(7):1916-25. Epub 2009 Jan 28. PubMed PMID: 19176753; PubMed Central PMCID: PMC2663925.

Babbin BA, Koch S, Bachar M, Conti MA, Parkos CA, Adelstein RS, Nusrat A, Ivanov AI. Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasion. Am J Pathol. 2009 Feb;174(2):436-48. Epub 2009 Jan 15. PubMed PMID: 19147824; PubMed Central PMCID: PMC2630553.

Schnoor M, Betanzos A, Weber DA, Parkos CA. Guanylate-binding protein-1 is expressed at tight junctions of intestinal epithelial cells in response to interferon-gamma and regulates barrier function through effects on apoptosis. Mucosal Immunol. 2009 Jan;2(1):33-42. Epub 2008 Sep 17. PubMed PMID: 19079332; PubMed Central PMCID: PMC2877263.

Chin AC, Lee WY, Nusrat A, Vergnolle N, Parkos CA. Neutrophil-mediated activation of epithelial protease-activated receptors-1 and -2 regulates barrier function and transepithelial migration. J Immunol. 2008 Oct 15;181(8):5702-10. PubMed PMID: 18832729; PubMed Central PMCID: PMC2778473.

Babbin BA, Laukoetter MG, Nava P, Koch S, Lee WY, Capaldo CT, Peatman E, Severson EA, Flower RJ, Perretti M, Parkos CA, Nusrat A. Annexin A1 regulates intestinal mucosal injury, inflammation, and repair. J Immunol. 2008 Oct 1;181(7):5035-44. PubMed PMID: 18802107; PubMed Central PMCID: PMC2778483.

Ivanov AI, Hopkins AM, Brown GT, Gerner-Smidt K, Babbin BA, Parkos CA, Nusrat A. Myosin II regulates the shape of three-dimensional intestinal epithelial cysts. J Cell Sci. 2008 Jun 1;121(Pt 11):1803-14. Epub 2008 May 6. PubMed PMID: 18460584.

Severson EA, Jiang L, Ivanov AI, Mandell KJ, Nusrat A, Parkos CA. Cis-dimerization mediates function of junctional adhesion molecule A. Mol Biol Cell. 2008 May;19(5):1862-72. Epub 2008 Feb 13. PubMed PMID: 18272784; PubMed Central PMCID: PMC2366836.

Laukoetter MG, Nava P, Lee WY, Severson EA, Capaldo CT, Babbin BA, Williams IR, Koval M, Peatman E, Campbell JA, Dermody TS, Nusrat A, Parkos CA. JAM-A regulates permeability and inflammation in the intestine in vivo. J Exp Med. 2007 Dec 24;204(13):3067-76. Epub 2007 Nov 26. PubMed PMID: 18039951; PubMed Central PMCID: PMC2150975.

Babbin BA, Jesaitis AJ, Ivanov AI, Kelly D, Laukoetter M, Nava P, Parkos CA, Nusrat A. Formyl peptide receptor-1 activation enhances intestinal epithelial cell restitution through phosphatidylinositol 3-kinase-dependent activation of Rac1 and Cdc42. J Immunol. 2007 Dec 15;179(12):8112-21. PubMed PMID: 18056353.

Lee WY, Weber DA, Laur O, Severson EA, McCall I, Jen RP, Chin AC, Wu T, Gernert KM, Parkos CA. Novel structural determinants on SIRP alpha that mediate binding to CD47. J Immunol. 2007 Dec 1;179(11):7741-50. Erratum in: J Immunol. 2008 Jan 1;180(1):665. Gernet, Kim M [corrected to Gernert, Kim M]. PubMed PMID: 18025220.

Reviews

Koch S, Nusrat A. The Life and Death of Epithelia During Inflammation: Lessons Learned from the Gut. Annu Rev Pathol. 2011 Jan 25. [Epub ahead of print] PubMed PMID: 21838548.

Koch S, Nusrat A. Dynamic regulation of epithelial cell fate and barrier function by intercellular junctions. Ann N Y Acad Sci. 2009 May;1165:220-7. Review. PubMed PMID: 19538310.

Ivanov AI, Parkos CA, Nusrat A. Cytoskeletal regulation of epithelial barrier function during inflammation. Am J Pathol. 2010 Aug;177(2):512-24. Epub 2010 Jun 25. Review. PubMed PMID: 20581053; PubMed Central PMCID: PMC2913378.

Severson EA, Parkos CA. Mechanisms of outside-in signaling at the tight junction by junctional adhesion molecule A. Ann N Y Acad Sci. 2009 May;1165:10-8. Review. PubMed PMID: 19538282.

Severson EA, Parkos CA. Structural determinants of Junctional Adhesion Molecule A (JAM-A) function and mechanisms of intracellular signaling. Curr Opin Cell Biol. 2009 Oct;21(5):701-7. Epub 2009 Jul 14. Review. PubMed PMID: 19608396; PubMed Central PMCID: PMC2776699.

Samarin S, Nusrat A. Regulation of epithelial apical junctional complex by Rho family GTPases. Front Biosci. 2009 Jan 1;14:1129-42. Review. PubMed PMID: 19273120.

Capaldo CT, Nusrat A. Cytokine regulation of tight junctions. Biochim Biophys Acta. 2009 Apr;1788(4):864-71. Epub 2008 Oct 8. Review. PubMed PMID: 18952050; PubMed Central PMCID: PMC2699410.

Schnoor M, Parkos CA. Disassembly of endothelial and epithelial junctions during leukocyte transmigration. Front Biosci. 2008 May 1;13:6638-52. Review. PubMed PMID: 18508684.

Laukoetter MG, Nava P, Nusrat A. Role of the intestinal barrier in inflammatory bowel disease. World J Gastroenterol. 2008 Jan 21;14(3):401-7. Review. PubMed PMID: 18200662; PubMed Central PMCID: PMC2679128.

Last updated September 2011

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